The division of cellular pathology consists of a highly skilled team of medical professionals engaged in providing the highest quality clinical service, research, and education, but our patient care activities are always our first priority. Through their roles as consultants and innovators, the team assists doctors and patients in making optimal decisions based on the latest diagnostic studies, using state-of-the-art instrumentation.
The Department of Cellular Pathology provides a comprehensive diagnostic service for patients receiving treatment for cancer and other serious illnesses at the Royal Surrey County Hospital/ RSCH (incorporating St. Luke’s Cancer Centre).
The Pathology Team consists of 8 consultants in Histopathology, 1 specialty doctor, 6 deanery registrars, one overseas trainee through MTI program, a group of highly skilled biomedical scientists (BMS) and medical laboratory assistants (MLA) and associated administrative staff/ secretaries. The Specialty Lead/ Head of Department is Dr Izhar Bagwan (Consultant Histopathologist).
Current research projects include:
Colorectal cancer project
Sponsor: Kingston University || Funder: Bright Charity
Epigenetic colon cancer treatment: a global systems approach to enhancement
Sponsor: University of Surrey || Funder: TBC
- Participation in various clinical trials including OCCAMS, ESPAC, etc
Clinicopathological and molecular studies in melanoma.
Partial funder: Cancer Research
Wang J, Taylor A, Showeil R, Trivedi P, Horimoto Y, Bagwan I, Ewington L, Lam EW, El-Bahrawy MA. Expression profiling and significance of VEGF-A, VEGFR2, VEGFR3 and related proteins in endometrial carcinoma. Cytokine. 2014 Aug;68(2):94-100.
Silvanto A, Hussain F, Riga A, Bagwan IN. Mucinous cystic neoplasm of common hepatic duct. Dig Liver Dis. 2014 Aug;46(8):762-4. doi: 10.1016/j.dld.2014.03.019. Epub 2014 Apr 30. No abstract available.
Khelwatty SA, Essapen S, Bagwan I, Green M, Seddon AM, Modjtahedi H. Co-expression of HER family members in patients with Dukes' C and D colon cancer and their impacts on patient prognosis and survival. PLoS One. 2014 Mar 7;9(3):e91139. doi: 10.1371/journal.pone.0091139. eCollection 2014.
Silvana Di Palma:
Di Palma S. Head and Neck Pathology: SY13-3 Carcinoma Ex Pleomorphic Adenoma. Pathology. 2014 Oct;46 Suppl 2:S19. doi: 10.1097/01.PAT.0000454115.41931.ca.
Simpson RH, Skálová A, Di Palma S, Leivo I. Recent advances in the diagnostic pathology of salivary carcinomas. Virchows Arch. 2014 Oct;465(4):371-84. doi: 10.1007/s00428-014-1639-x. Epub 2014 Aug 30. Review.
Di Palma S, Fehr A, Danford M, Smith C, Stenman G. Primary sinonasal adenoid cystic carcinoma presenting with skin metastases--genomic profile and expression of the MYB-NFIB fusion biomarker. Histopathology. 2014 Feb;64(3):453-5. doi: 10.1111/his.12261. Epub 2013 Nov 6. No abstract available.
Professor Martin Cook:
Jewell R, Elliott F, Laye J, Nsengimana J, Davies J, Walker C, Conway C, Mitra A, Harland M, Cook MG, Boon A, Storr S, Safuan S, Martin SG, Jirström K, Olsson H, Ingvar C, Lauss M, Bishop T, Jönsson G, Newton-Bishop J. The clinicopathological and gene expression patterns associated with ulceration of primary melanoma. Pigment Cell Melanoma Res. 2015 Jan;28(1):94-104. doi: 10.1111/pcmr.12315. Epub 2014 Oct 1.
Gerami P, Busam K, Cochran A, Cook MG, Duncan LM, Elder DE, Fullen DR, Guitart J, LeBoit PE, Mihm MC Jr, Prieto VG, Rabkin MS, Scolyer RA, Xu X, Yun SJ, Obregon R, Yazdan P, Cooper C, Weitner BB, Rademaker A, Barnhill RL. Histomorphologic assessment and interobserver diagnostic reproducibility of atypical spitzoid melanocytic neoplasms with long-term follow-up. Am J Surg Pathol. 2014 Jul;38(7):934-40. doi: 10.1097/PAS.0000000000000198.
Dr Peter Jackson:
Babar M, Madani R, Jackson P, Layer GT, Kissin MW, Irvine TE. One Step Nucleic Acid Amplification (OSNA) positive micrometastases and additional histopathological NSLN metastases: Results from a single institution over 53 months. Surgeon. 2014 Nov 1. pii: S1479-666X(14)00071-7. doi: 10.1016/j.surge.2014.06.001. [Epub ahead of print]
Babar M, Madani R, Thwaites L, Jackson PA, Devalia HL, Chakravorty A, Irvine TE, Layer GT, Kissin MW. A differential intra-operative molecular biological test for the detection of sentinel lymph node metastases in breast carcinoma. An extended experience from the first U.K. centre routinely offering the service in clinical practice. Eur J Surg Oncol. 2014 Mar;40(3):282-8. doi: 10.1016/j.ejso.2013.10.030. Epub 2013 Nov 21
- Immunohistochemistry Laboratory - comprising a large repertoire of antibodies and state-of-art instrumentation.
- Molecular Laboratory- including RT-PCR, Droplet PCR, NGS, etc